Scientist (I/II): Phage Display, Antibody Discovery & Engineering

About the Company:

Tentarix Biotherapeutics is a biotechnology company with a revolutionary platform for the discovery of next generation, multi-specific biologic drugs, with the potential to make a significant difference in the lives of patients suffering with diseases, such as cancer and autoimmunity.

We are led by a seasoned executive team with proven expertise in the field of multi-specific drug discovery, drug development, and company building. We are supported by top tier healthcare investors and have several ongoing partnered programs with Gilead and AbbVie.

We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape.

The Tentarix culture is founded on integrity, accountability, teamwork, and respect. Our team members are creative, hands-on, self-directed, and determined. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our team.

Role:

Tentarix is seeking a motivated Scientist (I/II) to join our Biotherapeutics Design team, with a focus on phage display and antibody engineering. This individual will support the discovery and development of Tentarix’s multi-specific “Tentacles” by contributing to antigen design, binder discovery by phage display, binder screening and characterization, and antibody engineering for lead optimization.

Key Responsibilities:

• Participate in all aspects of phage display campaigns for binder discovery, including library design, binder screening, and characterization
• Design antigens or antigen fragments for binder screening
• Contribute to antibody engineering, including affinity maturation/dematuration efforts to support advancement toward target product profiles
• Use protein engineering techniques, structural biology and bioinformatics tools to assist in optimizing candidate molecules for therapeutic function and removing sequence liabilities
• Contribute to the design, screening, and optimization of fully human Fab and VH-Select libraries
• Utilize molecular biology techniques to assist in library construction and expression system optimization
• Characterize binders and engineered molecules using ELISA, BLI, cell binding, DSF, and related methods
• Contribute to data analysis, documentation, and scientific discussions within and across teams
• Support the development of innovative screening and design methodologies for multi-specific biologics
• Communicate effectively across teams to promote project efficiency and technical collaboration
  
  

Qualifications and Skills:

• B.S/M.S. in life sciences, molecular biology, biochemistry or a related field with 7+ years industry experience, or Ph.D. in a related field with an emphasis on protein design; postdoctoral or 1–2 years industry experience preferred
• Experience with in vitro discovery technologies such as phage or yeast display
• Knowledge of protein biophysics and design, including practical experience with ELISA, BLI, DSF, or comparable methods
• Strong problem-solving skills and scientific rigor with a drive for innovation
• Organized, goal-oriented, and comfortable managing tasks across multiple projects and timelines
• Proven ability to contribute constructively in a collaborative, cross-functional team
• Excellent verbal and written communication skills
• Self-motivated, decisive, and proactive; thrives in a fast-paced, hands-on environment
• Demonstrated integrity, ethics, and commitment to high scientific standards
  
  

Compensation and Benefits:

The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including, but not limited to, skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. At Tentarix, it is not typical for an individual to be hired at or near the top of the range for their role, and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range is $104,000 – $140,000 + bonus target + benefits + equity.

Our employees are the Company’s most valuable asset, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Applicants must be currently authorized to work in the United States on a full-time basis.

Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.