Associate Scientist, in vivo Pharmacology

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company's approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a highly motivated and collaborative Associate Scientist to join our in vivo Pharmacology team. In this role, the Associate Scientist will perform hands-on in vivo studies utilizing murine oncology and non-oncology models, supporting the advancement of genetic medicines that leverage engineered recombinases delivered through non-viral methods. Reporting to the Senior Scientist of in vivo Pharmacology and working closely with cross-functional teams, this is a unique opportunity to work on the front lines of innovation and contribute to the advancement of transformational therapies.

Key Responsibilities & Accountabilities:

• Conduct experiments in murine oncology and non-oncology animal models to evaluate recombinase-based engineering of immune cells, including tumor cell injection/implantation, immune cell dosing, test article dosing, interval tissue collection, in-life bioimaging for tumor analysis and terminal tissue processing
• Additional responsibilities may include preparing tumor cells and PBMCs for injections, and processing samples for downstream analyses to support research objectives
• Work closely with in vivo pharmacology teammates to conduct in vivo experiments and coordinate ex vivo analyses
• Adhere to SOPs and IACUC protocols
• Analyze and interpret data and produce study reports to inform project direction
• Effectively communicate findings to internal teams
• Collaborate with internal cross-functional teams and external vendors to ensure seamless execution and progression of in vivo research programs
• Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards
• Collaborate with regulatory and preclinical teams to ensure robust documentation of non-clinical findings for submissions
  
  

Qualifications and Skills:

• Master's degree in Pharmacology, Immunology, Immuno-oncology, or a related field with 3+ years of relevant industry or academic experience, or a Bachelor's degree with 5+ years of experience
• Hands-on expertise in in vivo pharmacology, including mouse handling, surgical procedures, IV tail vein injection, body weight monitoring, blood collection, tumor model development and tumor growth analysis, tissue dissociation and processing
• Demonstrated ability to execute, interpret and troubleshoot in vivo studies
• Experience with thawing and dosing of T cells, PBMCs or other immune cell types into mice as well as with culturing tumor cells and establishing tumor models in mice
• Familiarity with T cell or PBMC isolation and handling from peripheral blood, and downstream immunological or molecular assays
• Experience with LNP or CART delivery technologies and genetic medicine platforms a plus
• Experience with ex vivo analytical techniques, such as flow cytometry, cytokine analysis and ddPCR, preferred
• Demonstrated ability to work independently and effectively with teammates in a laboratory setting, learn new techniques, multitask effectively and maintain meticulous records, including documenting and maintaining an organized lab notebook, lab inventory and experimental results
• Excellent communication skills, with a team-first mindset and the ability to convey technical information
• Analytical thinker with the ability to distill complex data into clear, actionable insights