Scientist, Cancer Metabolism

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description

Calico is seeking a highly motivated scientist to join and lead discovery research projects in the metabolism of aging group. Specifically, we are interested in applicants with an interest in understanding the role of metabolism in development and cancer. We seek expertise in combining cutting-edge molecular and biochemical techniques, including transcriptomics and metabolomics, with in vitro and in vivo models to uncover metabolic interactions in health and disease. Join our collaborative, cross-functional environment at the forefront of aging research, work alongside world-class technology labs, and lead ambitious research projects that could transform our understanding of the role of metabolism in vital processes.

Responsibilities

• Perform basic research to determine the role of metabolic interactions in tumor progression, metastasis to specific organs and therapy resistance
• Develop approaches to evaluate metabolic interactions between specific cell types during tumor progression and metastasis
• Publish papers and present findings both internally and at scientific conferences
  
  

Position Requirements

• PhD or MD/PhD in cell/molecular biology, biochemistry or a related field with 0-5 years of postdoctoral and/or industry experience
• Experience working with animal models to study human disease
• Deep knowledge of cellular and organismal metabolism and physiology
• Strong working knowledge of genetics, cell biology and molecular genetics
• Detail-oriented, organized and driven
• A track record of strong research productivity
• Strong teamwork and communication skills
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Must be willing to work onsite five days per week
  
  

Nice To Have

• Experience with mass spectrometry to measure metabolites and/or lipids and/or proteins
• Experience using stable isotope labeling to understand metabolic fluxes in vitro and/or in vivo
• Experience with cancer mouse models
• Experience with mouse models of brain tumors
• Experience in pediatric tumor biology
• Experience with integrating multiomics data
• Competence with mammalian tissue culture, in vitro gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods
• Familiarity with R or Python for data analysis and visualization
  
  

The estimated base salary range for this role is $135,000 - $163,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.